Depuydt P, Benoit D, Vogelaers D, Decruyenaere J, Vandijck D, Claeys G, Verschraegen G, Blot S.

Department of Intensive Care, Ghent University Hospital, Ghent, Belgium.

Intensive Care Med. 2008 Apr;34(4):675-82.

OBJECTIVE: To assess prediction of multidrug resistant (MDR) pathogens in ventilator-associated pneumonia (VAP) by systematic surveillance cultures (SC) and to assess the contribution of SC to initial antibiotic therapy.

DESIGN: Prospective cohort study of patients with microbiologically confirmed VAP. Comparison of actual early antibiotic coverage with three hypothetical empirical schemes.

SETTING: A 50-bed university hospital ICU. SC consisted of oral, nasal, urinary and rectal samples upon admission, 3-weekly urinary and 1-weekly oral, nasal, and rectal samples in all patients, 3-weekly tracheal aspirates in intubated patients.

RESULTS: MDR pathogens were found in 86 of 199 VAP episodes. Sensitivity of SC to predict MDR pathogens was 69% (tracheal SC) and 82% (all SC); specificity was 96% (tracheal) and 91% (all), respectively. Appropriate antibiotic coverage within 24[Symbol: see text]h and 48[Symbol: see text]h following MDR VAP was 77% and 89%, respectively. A carbapenem-based empirical scheme would have been equally appropriate (83% vs. 77% at 24[Symbol: see text]h; 83% vs. 89% at 48[Symbol: see text]h), but a beta-lactam-fluoroquinolone empirical therapy would have been less (59% vs. 77% at 24[Symbol: see text]h; 59% vs. 89% at 48[Symbol: see text]h) as would have been beta-lactam-aminoglycoside therapy (68% vs. 77% at 24[Symbol: see text]h; 68% vs. 89% at 48[Symbol: see text]h). Empirical comparators would have resulted in significantly more prescription of broad-spectrum antibiotics within the first 48[Symbol: see text]h.

CONCLUSIONS: With MDR pathogens highly prevalent, systematic SC predicted MDR pathogens causing VAP in 69% to 82% and may have contributed to high rates of early appropriate antibiotic therapy with limited use of broad-spectrum antimicrobials.