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Friday, 26 March 2010 |
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Jung YJ. et al
About this article:"Methicilin-resistant Staphilococcus aureus nosocomial pneumonia is a very severe infectious disease with a high mortality . Up to know vancomycin and linezolid are the two main antibiotics recommended in the guidelines for the treatment of this type of nosocomial pneumonia. In this randomized study the addition of rifampicin to vancomycin resulted in a higher significant clinical cure when compared to vancomycin alone. However, neither the micobiological eradication nor mortality differed between groups. This study was based on "in vitro data" that suggests that adding rifampicin to vancomycin increases the bactericidal activity particularly in foci in wich antibiotics are difficult to reach.Larger studies are warranted"
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Friday, 26 March 2010 |
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Bouhemad B. et al
About this article:"The clinical parameters for the follow-up evolution of VAP are not well established. Bed-side chest X-ray is not a very reliable technique in ventilated patients. Using a reparation socore authors found that lung bed side ultrasonography (reareation of more than 400 mL in the CT Scann) was associated with successful antimicrobial therapy. We do not know now how useful can be in the future the application of bed-side ultrasonography. However, and without no doubt , this technique opens new insights for the better assessment of VAP treatment response"
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Friday, 26 March 2010 |
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Garcin F. et al
About this article:"There is little evidence about the influence on outcome of adherence of guidelines in the treatment of VAP. In this observational study authors report 87% initial adequate antibiotic treatment in a series of VAP patients. In fifty cases difficult to treat bacteria were isolated. The risk factors included prior antimicrobial treatment, late -onset pneumonia, and health-care associated pneumonia. These cases represented the 23% of late-onset cases and were the main cause of initial inadequacy antibiotic therapy."
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Monday, 01 February 2010 |
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Abunasser J. et al
About this article:"This review article covers the controversy of Linezolid vs glycopeptides for the treatment of severe MRSA pneumonia. Although clinical studies are inconclusive., animal studies in a model of mecahnically ventilated piglet shows differences in favor of Linezolid compared to vancomycin and teicoplanin. These differences were attributed to other factors than direct antimicrobial properties."
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Monday, 01 February 2010 |
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Ferrari F. et al
About this article:"In this piglet mechanically ventilated animal model of Pseudomonas aeruginosa, partially resistant VAP , nebulized or systemic ceftazidime (MIC: 16 mg/L) were administered. Very interestingly, nebulized ceftazidime was more effective in killing Pseudomonas aeruginosa in lungs. This animal study support the concept of administering nebulized antibiotics in multidrug resistant microorganism VAP."
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